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Cunningham, John
One or more keywords matched the following properties of Cunningham, John
PropertyValue
keywords Stem Cell Transplantation
keywords Sickle Cell Disease
overview My research focuses on the biology and therapy of hemoglobinopathies, the molecular mechanisms underpinning hematopoiesis and the development of the leukemia stem cell, and the transcriptional mechanisms operative during the development of vertebrate organisms. Research projects include characterization of the key factors modulating developmental erythropoiesis, identification of gene regulatory networks in the neural crest and in neuroblastoma, and the development of allogenic stem cell transplant approaches to sickle cell disease. We collaborate with colleagues in developmental biology, informatics, and cancer biology to ensure that we bring a comprehensive perspective to the fundamental question we seek to solve.
One or more keywords matched the following items that are connected to Cunningham, John
Item TypeName
Concept Porphobilinogen Synthase
Concept Base Sequence
Concept Binding Sites
Concept Cell Separation
Concept Cushing Syndrome
Concept Graft Survival
Concept Cross-Sectional Studies
Concept Hematopoietic Stem Cells
Concept Sulfoxides
Concept Cohort Studies
Concept Software
Concept Hematopoietic Stem Cell Transplantation
Concept Electrophoretic Mobility Shift Assay
Concept Calcium Signaling
Concept Metabolic Syndrome
Concept Embryonic Stem Cells
Concept Position-Specific Scoring Matrices
Concept Endoplasmic Reticulum Stress
Concept Peripheral Blood Stem Cell Transplantation
Concept Oligonucleotide Array Sequence Analysis
Concept Interleukin Receptor Common gamma Subunit
Concept Adult Stem Cells
Concept Unfolded Protein Response
Concept High-Throughput Nucleotide Sequencing
Concept Survival Analysis
Concept Genes, myc
Concept Mice, 129 Strain
Concept Smad3 Protein
Concept Genome, Human
Concept Gene Silencing
Concept Sirtuins
Concept Tumor Suppressor Proteins
Concept Smad2 Protein
Concept Transcriptome
Concept Genome-Wide Association Study
Concept Cord Blood Stem Cell Transplantation
Concept Nitric Oxide Synthase Type III
Concept Acute Chest Syndrome
Concept Anemia, Sickle Cell
Concept Cell Survival
Concept Retrospective Studies
Concept Neoplastic Stem Cells
Concept User-Computer Interface
Concept Signal Transduction
Concept Tumor Suppressor Protein p53
Concept Mice, SCID
Concept Disease-Free Survival
Concept U937 Cells
Concept Polymorphism, Single Nucleotide
Concept Sirtuin 1
Concept Nucleotide Motifs
Academic Article Circadian variation in Cushing's disease and pseudo-Cushing states by analysis of F and ACTH pulsatility.
Academic Article Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions.
Academic Article Regulation of delta-aminolevulinic acid dehydratase by krüppel-like factor 1.
Academic Article The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.
Academic Article An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
Academic Article p19Arf represses platelet-derived growth factor receptor ß by transcriptional and posttranscriptional mechanisms.
Academic Article Tgfbeta signaling directly induces Arf promoter remodeling by a mechanism involving Smads 2/3 and p38 MAPK.
Academic Article The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Academic Article CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia.
Academic Article Bridging cancer biology with the clinic: relative expression of a GRHL2-mediated gene-set pair predicts breast cancer metastasis.
Academic Article Stem cell transplant as an immunomodulatory tool for children with hematologic malignancies.
Academic Article Collection of peripheral blood stem cells from a 7 month-old girl weighing 7 kg with the use of combined heparin and citrate anticoagulation.
Academic Article Systematic computation with functional gene-sets among leukemic and hematopoietic stem cells reveals a favorable prognostic signature for acute myeloid leukemia.
Academic Article Effects of late gestational high-fat diet on body weight, metabolic regulation and adipokine expression in offspring.
Academic Article Seq2pathway: an R/Bioconductor package for pathway analysis of next-generation sequencing data.
Academic Article A c-Myc-regulated stem cell-like signature in high-risk neuroblastoma: A systematic discovery (Target neuroblastoma ESC-like signature).
Academic Article Exosomes contribute to endothelial integrity and acute chest syndrome risk: Preliminary findings.
Academic Article Immune Reconstitution Following Autologous Stem Cell Transplantation in Patients with High-Risk Neuroblastoma at the Time of Immunotherapy.
Academic Article Incorporating genomic, transcriptomic and clinical data: a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma.
Academic Article CisPi: a transcriptomic score for disclosing cis-acting disease-associated lincRNAs.
Award or Honor Receipt Pritzker Professor
Award or Honor Receipt Bucksbaum Senior Fellow
Award or Honor Receipt George M. Eisenberg Professor
Academic Article Outcomes following second allogeneic stem cell transplant for disease relapse after T cell depleted transplant correlate with remission status and remission duration after the first transplant.
Academic Article PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.
Academic Article ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.
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  • National Heart Lung and Blood Institute
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